In the data panel you will see several columns of data:
- Gene name (symbol)
- Gene ID (see details in Search)
- UniProt ID
- Organism
- Protein name
(This information was extracted from the ProteinName field of the FASTA header in the UniProt protein FASTA file (https://www.uniprot.org/help/fasta-headers). - Known FunctionFunctional annotations (GO aspects Molecular Function (F) and Biological Process (P))
This information was extracted from GOC (http://geneontology.org/). Annotation supported by experimental evidence is indicated by a yellow flask icon. Annotation propagated from ancestral genes (GO evidence code IBA) . Only Molecular Function annotations with Experimental Evidence are shown. Experimental Evidence includesis indicated by a green tree glyph. Experimental evidence are:- IDA: direct assay
- IMP: mutant phenotype
- IGI: genetic interaction
- IPI: physical interaction
- IEP: expression pattern
EXP: experimental evidence
Each subheader under Known Function is a distinct known function reported for 
Within the Functional annotations, each listed GO term has annotation to at least one member of the gene family. If a YELLOW colored circle appears A yellow flask or a green tree icon in a gene row under underneath a subheader that GO term indicates the presence of that particular known function for in that gene supported either by experimental evidence or phylogenetic inference, respectively. Clicking on a YELLOW circle any of the icons will open a popup window where details about the function functional annotation can be found. The columns in the popup include:
- GO term: Shows the GO term name, which is hyperlinked to the term detail page in QuickGOGOC.
- Evidence description: Shows the experimental type of evidence that supports the annotation of the GO term to the gene/protein.
- Reference: Shows the publication(s) containing the experimental evidence supporting the GO annotation. We use digits (i.e., 1, 2, etc.) to indicate each distinct reference. Each number is a hyperlink to the PubMed record for the article.
- With/From: Displays other gene(s) that support the annotation. You will usually find it for annotations that were supported by physical interaction or genetic interaction evidence.
- Source: QuickGO. Clicking here More: Clicking 'QuickGO' takes you to the complete annotation record of the gene (UniProt protein) in QuickGO. Annotations displayed there are not limited to molecular functions that are supported by experimental evidence. You will likely find annotations to molecular functions with other types of evidence, and annotations to biological processes, or cellular components.
- Subfamily name
Subfamilies within each family are groups of genes that share a particularly high degree of similarity due to limited divergence from their common ancestor. Subfamilies are, in general, closely-related orthologs. More about subfamilies
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Tips: Only seeing partial text in some data cells? Mouse over the '...', a tool tip will popup in a few seconds with the complete text. |
Show/hide and reorder columns in the data panel
Clicking on the configuration icon located at the top left corner of data panel, you will see a popup menu.
Within the popup configuration menu you can:
- Check or uncheck a particular column or a particular GO term to see or hide it from the data panel.
- Use the up or down arrow to relocate (reorder) columns or GO terms.
Toggle to see the multiple sequence alignment (MSA) of a gene family
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