In the data panel you will see several columns:
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Within the Functional annotations, each listed GO term has annotation to at least one member of the gene family. A yellow flask or a green tree icon in a gene row underneath a GO term indicates the presence of that particular function in that gene supported either by experimental evidence or phylogenetic inference, respectively. Clicking on any of the icons will open a popup window where details about the functional annotation can be found. The columns in the popup include:
- GO term: Shows the GO term name, which is hyperlinked to the term detail page in GOC.
- Evidence description: Shows the type of evidence that supports the annotation of the GO term to the gene/protein.
- Reference: Shows the publication(s) containing the evidence supporting the GO annotation. We use digits (i.e., 1, 2, etc.) to indicate each distinct reference. Each number is a hyperlink to the PubMed record for the article.
- More: Clicking 'QuickGO' takes you to the complete annotation record of the gene (UniProt protein) in QuickGO. You will likely find annotations with other types of evidence, and annotations to cellular components.
- Subfamily name
Subfamilies within each family are groups of genes that share a particularly high degree of similarity due to limited divergence from their common ancestor. Subfamilies are, in general, closely-related orthologs. More about subfamilies
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- a darker shading over an amino acid residue indicates that the residue is shared by 90% or more sequences at the same position.
- a lighter shading indicates a residue shared by more than 50% but less than 90% of sequences.
- the identity is calculated by including all protein sequences in a PhyloGenes family.
- sequence similarity is recalculated when a user chooses to run ‘prune tree by organism’. The pruned protein sequences are excluded in recalculating sequence similarity.