Page Comparison

In the data panel you will see several columns of data:

• Gene name (symbol)
• Gene ID (see details in Search)
• UniProt ID
• Organism
• Protein name
  This information was extracted from the ProteinName field of the FASTA header in the UniProt protein FASTA file (https://www.uniprot.org/help/fasta-headers).
• Functional annotations (GO aspects Molecular Function (F) and Biological Process (P))
  This information was extracted from GOC (http://geneontology.org/). Annotation supported by experimental evidence (one of the evidence codes listed below) is indicated by a yellow flask icon. Annotation propagated from ancestral genes (GO evidence code IBA) is indicated by a green tree glyph.  Experimental Experimental evidence code includes:
  • IDA: direct assay
  • IMP: mutant phenotype
  • IGI: genetic interaction
  • IPI: physical interaction
  • IEP: expression pattern

  • EXP: experimental evidence

Each subheader under Functional annotation Within the Functional annotations (either 'F' for Molecular Function or 'P' for Biological Process) is a distinct , each GO term annotated has annotation to at least one member of the gene family. If a YELLOW flask A yellow flask or a GREEN green tree appears icon in a gene row under underneath a subheader it GO term indicates the presence of that particular function in that gene supported either by experimental evidence or phylogenetic inference, respectively. Clicking on a YELLOW circle an icon will open a popup window where details about the function functional annotation can be found. The columns in the popup include:

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  • GO term: Shows the GO term name, which is hyperlinked to the term detail page in QuickGOGOC.
  • Evidence description: Shows the experimental type of evidence that supports the annotation of the GO term to the gene/protein.
  • Reference: Shows the publication(s) containing the experimental evidence supporting the GO annotation.  We use digits (i.e., 1, 2, etc.) to indicate each distinct reference. Each number is a hyperlink to the PubMed record for the article.
  • With/From: Displays other gene(s) that support the annotation. You will usually find it for annotations that were supported by physical interaction or genetic interaction evidence.
    
  • Source: QuickGO. More: Clicking here takes you to the complete annotation record of the gene (UniProt protein) in QuickGO. Annotations displayed there are not limited to molecular functions that are supported by experimental evidence. You will likely find annotations to molecular functions with other types of evidence, and annotations to biological processes, or cellular components. 
    
• Subfamily name
  Subfamilies within each family are groups of genes that share a particularly high degree of similarity due to limited divergence from their common ancestor. Subfamilies are, in general, closely-related orthologs. More about subfamilies

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Show/hide and reorder columns in the data panel

Toggle to see the multiple sequence alignment (MSA) of a gene family

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