In the data panel you will see several columns of data:
- Gene name (symbol)
- Gene ID (see details in Search)
- UniProt ID
- Organism
- Protein name
(This information was extracted from the ProteinName field of the FASTA header in the UniProt protein FASTA file (https://www.uniprot.org/help/fasta-headers). - Known FunctionGene functional annotations (GO aspects Molecular Function (F) and Biological Process (P))
This information was extracted from GOC (http://geneontology.org/). Only Molecular Function annotations with Experimental Evidence are shown. Annotation supported by Experimental Evidence (one of the evidence code listed below) is indicated by a yellow flask icon. Annotation propagated from ancestral genes (GO evidence code IBA) is indicated by a green tree glyph. - Experimental Evidence includes:
- IDA: direct assay
- IMP: mutant phenotype
- IGI: genetic interaction
- IPI: physical interaction
- IEP: expression pattern
EXP: experimental evidence
...
Each subheader under Known Function is a distinct known function reported for at least one member of the gene family. If a YELLOW colored circle appears in a gene row under a subheader that indicates presence of that particular known function for that gene. Clicking on a YELLOW circle will open a popup window where details about the function annotation can be found. The columns in the popup include:
- GO term: Shows the GO term name, which is hyperlinked to the term detail page in QuickGO.
- Evidence description: Shows the experimental evidence that supports the annotation of the GO term to the gene/protein.
- Reference: Shows the publication(s) containing the experimental evidence supporting the GO annotation. We use digits (i.e., 1, 2, etc.) to indicate each distinct reference. Each number is a hyperlink to the PubMed record for the article.
- With/From: Displays other gene(s) that support the annotation. You will usually find it for annotations that were supported by physical interaction or genetic interaction evidence.
- Source: QuickGO. Clicking here takes you to the complete annotation record of the gene (UniProt protein) in QuickGO. Annotations displayed there are not limited to molecular functions that are supported by experimental evidence.You will likely find annotations to molecular functions with other types of evidence, and annotations to biological processes, or cellular components.
- Subfamily name
Subfamilies within each family are groups of genes that share a particularly high degree of similarity due to limited divergence from their common ancestor. Subfamilies are, in general, closely-related orthologs. More about subfamilies
...